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Extra info for Animals in Scientific Research: An Effective Substitute for Man?: Proceedings of a Symposium held in April 1982 under the auspices of the Humane Research Trust

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Brankow, D. W. and Heidelberger, C. (1973). Quantitative and qualitative studies of chemical transformation of cloned C3H mouse embryo cells sensitive to post-confluence inhibition of cell division. Cancer Res. 33, 3239-3249. Rosenkranz, H. , Hyman, J. and Leifer, J. (1981). DNA polymerase deficient assay. In Evaluation of Short-Term Tests for Carcinogens, (eds. J. de Serres and J . Ashby). 210-218. Scott , D. (1982). UKEMS Collaborative genotoxicity trial, cytogenetic tests of 4CMB, BC and 4HMB: Summary and appraisal.

Production of chromosome damage . the cell is shown with only 2 pairs of chromosomes . non disjunction translocat ion Interchange - - - - . deletion ~ At least a fraction of the chemicals which enter the human environment. either as pollutants or for specific purposes such as medicines. may be capable of producing mutagenic and/or carcinogenic damage to exposed individuals. Such damage may give rise to increases in the frequencies of tumours amongst the present population and also to increases in the frequency of congenital abnormalities in future generations.

REFERENCES Ahr, H. , King, L. , Nastainczyk, W. and Ullrich, V. (1980) The mechanism of chloroform and carbon monoxide formation from carbon tetrachloride by microsomal cytochrome P-450. Biochem. , 29,2855-2861. 26 Bachur, N. , Gordon, S. , Gee, M. V. and Kon, H. (1979) NADPHcytochrome P-450 reductase activation of quinone anticancer agents to free radicals. , 76, 954-957. Bishun, N. , Williams, D. C. and Parke, D. V. (1975) A cytogenic study in women who had used oral contraceptives, and their progeny.

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