By Colin F. Poole, Hal T. Butler, Myra E. Coddens, Sheila A. Schuette (auth.), Donald M. Wieland, Michael C. Tobes, Thomas J. Manger (eds.)
In 1906, Michael T. candy first constructed the chromatographic strategy through the use of an adsorbant to split pigments. when you consider that that point, the technological advances in TLC and HPLC have led to new definitions of purity in parallel with the advances. Radiopharmaceutical chemistry is mainly depending on the chromat ographic strategy due to the really small volume of fabric in such a lot radiopharmaceuticals-often so small that the standard actual tools of analytical chemistry can't be used. accordingly, this number of papers represents the foremost to winning radiopharmaceutical improvement through atmosphere the normal for the pres of radiochemical purity. ent-day definition William C. Eckelman, Ph.D. Diagnostics affiliate Director The Squibb Institute for clinical learn New Brunswick, New Jersey Preface The chapters herein are up to date and increased models of shows that the authors made at a symposium hung on June four, 1984 in la, California less than the sponsorship of the Radiopharmaceutical technological know-how Council of the Society of Nuclear medication. All manuscripts have been refereed. The motive of the symposium organizers used to be to enlist contributors who paintings on a daily foundation with the analytical and chromatographic suggestions to be mentioned on the symposium. We suppose convinced that this distillation of hands-on adventure can be of worth to graduate scholars in addition to skilled researchers in radio pharmaceutical chemistry and comparable fields which use radiotracer methodology.
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Additional resources for Analytical and Chromatographic Techniques in Radiopharmaceutical Chemistry
If colloidal 99mTc is being measured, then the strip is cut 3/4" from the bottom and the colloidal 99mTc is calculated as the percentage of the total activity that is present in the bottom 3/4" strip. a used. Because SnClz is present in excess quantities in most radiopharmaceutical kits, a spike of additional 99mTcOi into a labeled kit will not be measurable as 99mTcOi once added, since it is reduced and is then present in the "bound" state. 4. Basically, this procedure involves the addition of sufficient 99mTc04' to completely oxidize the Sn2+ present (after the initial 99mTc04' labeling), followed by further addition of known quantities of 99mTcOi .
This chapter covers the use of ITLC (instant thin-layer chromatography), TLC, mini-column and electrophoretic separation methods in radiopharmaceutical analyses, with particular emphasis on applications to 99ffiTc-based radiopharmaceuticals. A review is given of some, but by no means all, of the literature in these areas, along with a discussion of the use of these techniques in the radiopharmaceutical laboratories at Dupont-NEN Products. It is not my intention to cover radio-HPLC because it is reviewed elsewhere in this volume.
For example, it has been found that the use ofMEK is preferred over acetone as the developing solvent for the measurement of 99mTcOi in 99mTc-Glucoheptonate and other 99mTc-Iabeled products. 2 compare the use of these solvents for the measurement of 99mTcO,j in 99mTc-Glucoheptonate. The acetone system for the ITLC-SG assay of 99mTcO,j tends to be erratic and biased high (relative to the MEK system). The problem with acetone is most likely due to the fact that the 99mTc-Iabeled material is highly water soluble in nature (highly polar), and acetone has a higher dielectric constant than MEK and also, generally, has a higher water content than MEK.