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By Alexandra Columbus

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N Eng J Med 1979, 301, 942. [47] Lingjaerde O, Edlund AH, Gormsen CA, Gottfries CG, Haugstad A, Hermann IL, Hollnagel P, Makimattila A, Rasmussen KE, Remvig J, Robak OH. The effect of lithium carbonate in combination with tricyclic antidepressants in endogenous depression. Acta Psychiatr Scand 1974, 50, 233-242. [48] Luria SE. A Slot Machine, a Broken Test Tube: An Autobiography. Harper and Row, New York 1984. Fifty-Five Years of Lithium Therapy in Contemporary Psychiatry 33 [49] Maj M, Pirozzi R, Magliano L.

However, the circumstances for doing this were not too favorable. First, in the United States in late 1940s, the recommendations for low-salt diet were implemented for patients with cardiovascular diseases. It seemed that, for this aim, lithium chloride could be a good replacement for sodium chloride in the diet. However, as was demonstrated in 1960s, low sodium intake results in the enhancement of lithium reabsorption in kidneys what leads to an increase of lithium concentration in the organism and impending lithium toxicity.

Prophylactic lithium: double-blind discontinuation in manic-depressive and recurrent depressive disorders. Lancet 1970; 2: 326-330. Bach RO, Specter S. Antiviral activity of lithium ion with adjuvant agents. In: Birch NJ (ed) Lithium: Inorganic Pharmacology and Psychiatric Use. Oxford, IRL Press, 1988, 91-92. Baldessarini RJ, Tondo L. Does lithium treatment still work? Evidence of stable response over three decades. Arch Gen Psychiatry 2000; 57: 187-190. Fifty-Five Years of Lithium Therapy in Contemporary Psychiatry [9] [10] [11] [12] [13] [14] [15] [16] [17] [18] [19] [20] [21] [22] [23] [24] [25] [26] [27] [28] 31 Barraclough B.

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