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By Henry G. Kunkel (ed.), Frank J. Dixon (ed.)

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1980a). Such treated cells, however, could proliferate when a preparation of Iabearing spleen accessory cells was added to the culture. The accessory MACROPHAGES IN ANTIGENIC STIMULATION 19 cells were adherent to glass, lacked T-cell determinants, and contained two I-region determinants, one mapped to I-A, the other mapped from I-B to I-EIC. The accessory cell lacking Ia reconstituted the response but not as effectively, although, in their studies, a complete titration of each cell was not shown.

In their experiments, cortisone-resistant thymocytes developed into helper T cells upon culture with hemocyanin or fowl y-globulin. An excellent dose-response relationship was obtained, depending on the number of macrophages added to the culture. The primed T cells also generated an important nonspecific helper effect (assayed by challenging with DNP on an unrelated carrier protein) that was most pronounced with high numbers of T cells. Erb and Feldman made a number of observations regarding the role of the macrophage in the generation of helper T cells.

1978), or to endotoxin (Lemke and Opitz, 1976). , 1977, 1979). Broome and Jeng in their study went on to test various thiols trying to establish a functional-structural relationship. Various thiols and their disulfides promoted growth, in decreasing order of activity-for example, thioglycerol, the most potent of all, 2-ME mercaptopropionic acid, and cysteamine. Several substitutions of the basic thioethane compound resulted in changes, but the relationship of these with the growth potential was not found.

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