By Flan Garvey
A Masters’ thesis submitted to the varsity of industrial, Humanities and Social reports within the Institute of expertise, Tralee, eire
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Extra resources for A study of the “Saíocht” of a parish in Co. Clare
1. In contrast with its inhibitory role in astrogliogenesis, Ascl1 has a positive role in the development of oligodendrocytes, as it is required for the specification of oligodendrocyte progenitors in the embryonic ventral telencephalon and in the postnatal brain (Parras et al. 2004; Parras et al. 2007). The switch from the neurogenic to the oligodendrogenic function of Ascl1 may involve a cooperation with the transcription factor Olig2 as well as a Notch-mediated repression of the neurogenic factors Dlx1/2 (Parras et al.
Neural Dev 6:12 Chapter 3 The Role of the Transcription Factor Pax6 in Brain Development and Evolution: Evidence and Hypothesis Noriko Osumi and Takako Kikkawa Abstract During mammalian corticogenesis, the dorsal telencephalon is patterned through secreted molecules and transcription factors. Expression of the transcription factor Pax6 demarcates the dorsal telencephalon, thereby patterning the future cortical primordium. Pax6 is also crucial in neurogenesis in the developing cortex through its role in balancing proliferation and differentiation of neural progenitor cells (NPCs).
G. g. Btg2, Gadd45g, Ccng2), thus suggesting that Ascl1 has a dual role in cell cycle control during neurogenesis, promoting sequentially cell cycle progression of neural progenitors and subsequently their cell cycle exit (Castro et al. 2011). 34 J. Heng and F. Guillemot Fig. 5 Neurog2 and Ascl1 control the major steps of neurogenesis through direct regulation of multiple target genes. Top panel: Only relatively few of the direct target genes of Neurog2 in the developing telencephalon are known since no genome-wide chromatin immunoprecipitation analysis has been published yet.